Therapeutics Research

Therapies for treat COVID-19 can be placed into two broad categories:

• Therapeutics that treat viral infection.
• Therapeutics that mitigate COVID-19 complications and/or comorbid conditions.

In this section we highlight what we believe are among the most promising therapies being offered today.  Members should submit new developments or advancements  for review and possible inclusion in this section. 


The MATH+ Hospital Treatment Protocol for Covid-19 is a physiologic-based combination treatment regimen developed by group of colleagues with over 200 years of combined experience in Critical Care and Emergency Medicine. The protocol , called “MATH+” is intended for use in the hospitalized patient, with an emphasis on early initiation — as soon as the patient develops a need for supplemental oxygen.  All component medicines are FDA-approved, inexpensive, readily available and have been used for decades with well-established safety profiles. Brief video describes. 

MATH+ hospitals have been reporting hospital mortality between 4% and 10%  as opposed to approximately 23%. (As of July 2020) from published reports in the US, Italy, and China.  


A paper authored by 23 physicians (currently in pre-print) outlines key pathophysiological principles that relate to the patient with early infection treated at home.  Their conclusion is that it is conceivable that some if not a majority of hospitalizations could be avoided with a treat-at-home first approach with appropriate telemedicine monitoring and access to oxygen and therapeutics.

An algorithm based on age and comorbidities that allows for a large proportion to be monitored and treated at home during self-isolation with the aim of reducing the risks of hospitalization and death.

Therapeutic approaches based on these principles:

  • reduction of re-inoculation
  • combination antiviral therapy
  • immunomodulation
  • antiplatelet/antithrombotic therapy
  • administration of oxygen, monitoring, and telemedicine

The paper discusses the following:

  • Control of Contagion
  • Reduction of Self-Re-inoculation
  • Combination Antiviral Therapy
  • Zinc Lozenges and Zinc Sulfate
  • Antimalarials
  • Azithromycin
  • Doxycycline
  • Favipiravir
  • Immunomodulators
  • Colchicine
  • Antiplatelet Agents and Antithrombotics
  • Delivery of Oxygen and Monitoring
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