NONPROFIT, NONPARTISAN PLATFORM OF ACCURATE SCIENCE-BASED SOLUTIONS TO COVID-19

Luminostics

Business Name:
Luminostics
Business Genre:
Business Description:

Luminostics is an early-stage venture in Silicon Valley that is trying to develop diagnostics for at home use. After founding the company, the Luminostics team “spent four years working on home kits to allow consumers to privately test for infections like Chlamydia, Gonorrhea, and the flu using a smartphone attachment and a patented nanoparticle.”  [3] [5]

City:
Palo Alto
State:
CA
Country:
USA
Data/Evidence of Effectiveness:
The test is in development. There is no data for their COVID test. They have published papers about their technology for other applications. [7] [8]
Complimentary Products Needed to Perform Test:
swabs and blood collection kits? [6]
Setting of Care:
At home or perhaps small clincs [1][2]
Current Status / Clinical Development Stage / Expected Milestones:
Sanofi “signed an agreement to evaluate a collaboration on a unique self-testing solution for COVID-19” and “Luminostics would contribute its proprietary technology for consumer-diagnostics for COVID-19 testing while Sanofi would bring its clinical research testing experience and capabilities.” [10] “The company was on track to enter FDA trials with a mid- to late-2021 target for reaching the market” for diagnostics for tests like Chlamydia, Gonorrhea, and the flu [5]
Funding & Ownership :
Luminostics has seed funding (convertible note) from Khosla Ventures, Y Combinator, and Lynett capital, the amounts of funding are undisclosed. The Y Combinator is a Silicon Valley based start-up accelerator. [3] [4]
Business Model:
They are funded by venture [3]
IP:
Andrew Paterson and Richard Willson have a patent called “Phosphorescent reporters” that resembles the tech in Luminostics [9]
History & Origins :
Andrew Paterson and Bala Raja published the concept for the tech involved for in Luminostics as part of his Ph.D. research in Richard Willson’s lab in the Department of Chemical & Biomolecular Engineering at the University of Houston. The 2016 paper published in Lab on a Chip was entitled “A Low-Cost Smartphone-Based Platform for Highly Sensitive Point-of-Care Testing with Persistent Luminescent Phosphors” [7]
Date EUA Issued:
N/A
Sources:
[1] https://luminostics.com/ [2] https://luminostics.com/technology [3]https://www.crunchbase.com/organization/luminostics-inc [4] https://luminostics.com/company [5] https://www.inc.com/matt-haber/retooling-an-at-home-sti-test-for-covid-19.html [6] https://www.ycombinator.com/covid [7] Paterson AS, Raja B, Mandadi V, et al. A Low-Cost Smartphone-Based Platform for Highly Sensitive Point-of-Care Testing with Persistent Luminescent Phosphors. Lab Chip. 2017;17(6):1051-1059. doi:10.1039/c6lc01167e [8] Goux HJ, Raja B, Kourentzi K, et al. Evaluation of a nanophosphor lateral-flow assay for self-testing for herpes simplex virus type 2 seropositivity. Cheshenko NV, ed. PLOS ONE. 2019;14(12):e0225365. doi:10.1371/journal.pone.0225365 [9] https://patents.google.com/patent/EP3036530B1/en?inventor=andrew+paterson&oq=andrew+paterson [10]
Organization:
Their CEO is Bala Raja and their CTO is Andrew Paterson, who are both the founders of the company [3] [4]
No. Tests Per Day:
30 minutes per test. 24 hours per day x 2 test per hour= 48 tests
Time to Result:
5-30 minutes [2]
Test Sample Type:
respiratory samples and finger-stick blood [6]
Technology Overview:
CLIP device attaches to a smartphone that could be used at home or small clinics. To use, simply insert a consumable cartridge, insert a swab and break it-off, turn a knob to release buffer, and then wait 5-30 minutes for your phone to provide test results [2]. Few specific details have been released about their COVID test, but generally speaking, their technology is a lateral flow strip that contains antibodies conjugated to strontium aluminate nanophosphors, which serve as persistent luminescent reporters. Luminostics’ software “controls the smartphone’s flash to excite the nanophosphors” and “the smartphone camera captures an image of the persistent luminescence from the reporters” . Their software then compares luminescence of the control and test lines to give a result. [7]
Testing Type:
According to the Y Combinator website, the diagnostic is a “15-minute point-of-care test for the simultaneous detection of SARS-CoV-2 virus from respiratory samples (to diagnose active COVID-19 infection) and anti-SARS-CoV-2 IgG/IgM antibodies from finger-stick blood (to test for COVID-19 immunity)” [6]
Test Category:
SEROLOGY
Test Name:
CLIP-COVID19
Clinical Application & Need:
acute infection [2]
Age of Company:
2014 [3]

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